Chemistry · A-Level · AQA · AQA A-level Chemistry - (7405) · Specification point · 3.3.13.5 · Organic chemistry · Amino acids, proteins and DNA (A-level only)
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3.3.13.5 Action of anticancer drugs (A-level only)
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The Pt(II) complex cisplatin is used as an anticancer drug. Cisplatin prevents DNA replication in cancer cells by a ligand replacement reaction with DNA in which a bond is formed between platinum and a nitrogen atom on guanine. Appreciate that society needs to assess the balance between the benefits and the adverse effects of drugs, such as the anticancer drug cisplatin. Students should be able to:
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