Acylation (A-level only) (3.3.9.2) | AQA A-level Chemistry - (7405) | KnowledgeSet

Acylation (A-level only)

Chemistry · A-Level · AQA · AQA A-level Chemistry - (7405) · Specification point · 3.3.9.2 · Organic chemistry · Carboxylic acids and derivatives (A-level only)

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3.3.9.2 Acylation (A-level only)

Content	Opportunities for skills development
$The structures of: acid anhydrides acyl chlorides amides. The nucleophilic addition-elimination reactions of water, alcohols, ammonia and primary amines with acyl chlorides and acid anhydrides. The industrial advantages of ethanoic anhydride over ethanoyl chloride in the manufacture of the drug aspirin. Students should be able to outline the mechanism of nucleophilic addition-elimination reactions of acyl chlorides with water, alcohols, ammonia and primary amines.$	$AT d and k PS 2.2 Students could record observations from reaction of ethanoyl chloride and ethanoic anhydride with water, ethanol, ammonia and phenylamine. AT b, d, g and h PS 2.1, 2.3 and 4.1 Students could carry out the preparation of aspirin, purification by recrystallisation and determination of its melting point. Students could carry out the purification of impure benzoic acid and determination of its melting point.$

Content

Opportunities for skills development

The structures of: acid anhydrides acyl chlorides amides. The nucleophilic addition-elimination reactions of water, alcohols, ammonia and primary amines with acyl chlorides and acid anhydrides. The industrial advantages of ethanoic anhydride over ethanoyl chloride in the manufacture of the drug aspirin. Students should be able to outline the mechanism of nucleophilic addition-elimination reactions of acyl chlorides with water, alcohols, ammonia and primary amines.

AT d and k PS 2.2 Students could record observations from reaction of ethanoyl chloride and ethanoic anhydride with water, ethanol, ammonia and phenylamine. AT b, d, g and h PS 2.1, 2.3 and 4.1 Students could carry out the preparation of aspirin, purification by recrystallisation and determination of its melting point. Students could carry out the purification of impure benzoic acid and determination of its melting point.